New project will develop nanoparticles with imaging and medicine-delivery capabilities to better treat PAD

kytai nguyen
Kytai Nguyen
Credit: University of Texas at Arlington

A University of Texas at Arlington bioengineer is leading a project to develop biodegradable nanomaterials that will take pictures and deliver medicine to combat peripheral arterial disease (PAD), the university announced in a press release.

Kytai Nguyen, a UTA bioengineering professor, is the principal investigator in the four-year, $2.1 million National Institutes of Health (NIH) grant-funded project. She is collaborating with Jian Yang, a Penn State University in University Park, Pennsylvania, bioengineering professor and former UTA faculty member, and Ralph Mason, a professor of radiology at UT Southwestern in Dallas, Texas.

“What is important in this project is that the technology carries fluorescent and ultrasound imaging capabilities, which will provide patients and doctors with more detailed information,” Nguyen said. “It also gives patients more targeted medicine, making it more efficient.”

PAD, more commonly known as either atherosclerosis, is a condition commonly found in the elderly. It affects more than 200 million people worldwide and is associated with high rates of morbidity and mortality.

The research aims to develop novel biodegradable nanoparticles to deliver therapeutic agents that specifically protect cells under stress conditions, facilitate the formation of blood vessels under hypoxia and allow noninvasive multimodal imaging methods.

One impact of the research is to use these new nanoparticle platforms to deliver any therapeutics locally, treat the disease effectively and monitor the treatment noninvasively by imaging. “The overall goal is to reduce complications and improve the quality of life for PAD patients,” Nguyen said.

Michael Cho, chair of the UT Arlington Bioengineering Department, said Nguyen’s innovative research could greatly help those who live with PAD.

“This cutting-edge technology has a chance to change our protocols on how to deal with atherosclerosis,” Cho said. “When you are able to target localized lesions for treatment, that is so much better for the patients and much less invasive than current treatment.”

Nguyen, who has been at UTA since 2005, received Cancer Prevention & Research Institute of Texas grants in 2010, 2016, and 2021. She also has received funding through the NIH, National Science Foundation, American Heart Association, and U.S. Departments of Education and Defense, among others.


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