Research indicates low stroke risk and benefit of medication alone in asymptomatic carotid stenosis

Robert Chang

The risk of having a future stroke caused by asymptomatic carotid stenosis is “so low” that most patients with this condition could potentially be treated with the newest medications and may not require surgery. That is according to new research from Kaiser Permanente.

“The question of how to best treat patients with narrowing of the carotid artery without symptoms has been a longstanding research priority,” said Robert Chang, MD, the assistant chair of vascular surgery for the Permanente Medical Group in Oakland, California. “We decided to take a step back and begin our study by asking how likely it is that these patients will actually have a stroke related to their severe stenosis. Our analyses showed that this risk is so low that it appears that, for most patients, surgery may not be necessary.”

The study, published in May in The Journal of the American Medical Association (JAMA), is believed to be the largest and most current assessment of long-term stroke risk in this population, according to Kaiser Permanente.

Carotid stenosis occurs when plaque builds up in one or both of the large arteries on either side of the neck that carry blood to the brain, face, and head. This narrowing in the artery is typically diagnosed after a patient has experienced symptoms of a stroke, but it can also be found during a routine physical examination.

Randomized clinical trials conducted prior to 2010 concluded that surgery to remove the blockage was the best option for reducing stroke risk in patients with severe stenosis. But, as medical treatments for reducing stroke risk have improved, physicians have begun to wonder whether surgery should remain the preferred treatment for asymptomatic patients, a Kaiser Permanente press release states.

To answer that question, Chang and his colleagues identified 3,737 Kaiser Permanente members in Northern California who had been diagnosed with severe asymptomatic carotid stenosis (70–99% blockage) between 2008 and 2012. None of these patients had previously had surgery.

The research team first looked to see how the stenosis had been treated. Reviewing the patients’ medical records showed that 1,423 patients had had surgery to treat the stenosis, and 2,314 had not. The team also tracked which patients were taking a statin to help lower cholesterol in the blood or medication to reduce high blood pressure. Next, the team looked to see how many patients had a carotid-related stroke on the same side as the severe carotid stenosis. They followed the patients through 2019.

Overall, 133 strokes were diagnosed in 129 patients during the follow-up period. Statistical analyses showed that the patients who did not have surgery had a 4.7% cumulative risk of having a stroke within five years of their carotid stenosis diagnosis.

The study’s senior author, Mai Nguyen-Huynh, MD, from the Permanente Medical Group in Oakland, California, said the findings did not surprise her. “We suspected that we may find a low risk of stroke in these patients because there are now better stroke-prevention treatments, including medications to control blood pressure, prevent blood clots, and reduce cholesterol, than when the original randomized trials were done,” she said. “I think our study will make many patients and their doctors think twice about surgery if they can instead be on an effective aggressive medical management program to lower their stroke risk from asymptomatic carotid disease.”

Chang and Nguyen-Huynh also currently lead a team at the Kaiser Permanente division of research affiliated with the national, randomized clinical trial, CREST-2, that is enrolling patients in a study comparing surgery or stenting to medical management in patients with asymptomatic severe carotid stenosis. “This head-to-head comparison of carotid surgery versus medical management in a clinical trial is what we need to help us determine the appropriate approach,” Nguyen-Huynh added.


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