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Tackling health insecurity ‘from the top down and the bottom up’
The feeling of being “uncertain, anxious and vulnerable” defines a creeping health insecurity problem riddling parts of the U.S. patient population—demographics who are underserved and at higher risk of outcomes such as amputation. And they can be a barrier to…
Results from PROMISE II pivotal trial published, reinforcing ‘ transformational value’ of deep vein arterialization in no-option CLTI patients
Results from the PROMISE II pivotal trial investigating transcatheter arterialization of the deep veins using the LimFlow system in so-called no-option chronic limb-threatening ischemia (CLTI) patients were today published in the New England Journal of Medicine (NEJM). The publication confirmed…
SCVS 2023: Endovascular-first or -only approach to all CLTI patients ‘is not evidence-based care’
Michael S. Conte, MD, one of the foremost experts in the field of peripheral arterial disease (PAD), took attendees of the 2023 annual meeting of the Society for Clinical Vascular Surgery (SCVS) in Miami on a journey through the decades…
VESS 2023: pMAC score found to be ‘important predictor’ of CLTI revascularization outcomes
Having observed a strong relationship between calcification and subsequent limb loss, a research team led by investigators from the University of California San Francisco (UCSF) have conducted a single-center, retrospective follow-up extending an initial study evaluating pedal medial arterial calcification…
‘Urgent action needed’ to improve implementation of guideline-directed medical therapy for PVI
Almost one-half of the patients receiving a peripheral vascular intervention (PVI) in the Society for Vascular Surgery (SVS) Vascular Quality Initiative (VQI) registry between 2017 and 2018 were not on guideline-directed medical therapy (GDMT). Kim G. Smolderen, PhD, and Carlos…
BioGenCell begins recruitment for clinical trial of stem cell-based treatment for preventing limb amputation
BioGenCell has announced that it is recruiting for an international clinical trial to assess the company’s stem cell-based therapy for chronic limb-threatening ischemia patients who are at risk for limb amputation. The clinical trial is currently taking place in medical…
Study: Combined antiplatelet, NOAC use linked to worse limb outcomes after suprainguinal bypass
A new analysis that found combined antiplatelet and novel oral anticoagulant (NOAC) therapy after suprainguinal bypass was associated with worse limb outcomes and equivalent survival compared to antiplatelet use alone has “weaknesses” but is “hypothesis-generating,” the senior author insisted during…
Six-month data from SWING below-the-knee, first-in-human trial presented at AMP Europe
Six-month data from the Surmodics SWING first-in-human (FIH) study of the company’s Sundance sirolimus drug-coated balloon (DCB) were shared at the 2022 Amputation Prevention Symposium (AMP) held Oct. 9–11 in Lugano, Switzerland. The SWING study is a prospective, multicenter, single-arm feasibility study to evaluate…
Study is first to elucidate lower-limb amputation epidemiology in a Latin American low- and middle-income country
A study recently published in the World Journal of Surgery claims to be the first to provide comprehensive population-level data on the epidemiology of lower-extremity amputation (LEA) in a Latin American low- and middle-income country (LMIC). The investigators write that their…
Limb salvage in focus: New VAM lectureship, born of a pioneering spirit, thrills honoree
It all started around the late 1970s, early 1980s. Back then, recalls Frank J. Veith, MD, the notion of aggressively pursuing limb salvage in a gangrenous foot or toe went against the grain of current thinking. What Veith and his…